Physical Function Assessment Core (FAC)
Core Directors: Roger A. Fielding, Ph.D
Alan Jette, Ph.D.
Thomas Storer, Ph.D.
The FAC represents a strategic interdisciplinary alliance between the Muscle Mechanics and Metabolomics Laboratory, the Laboratory of Exercise Physiology and Physical Performance and the Health and Disability Research Institute at Boston University and the Nutrition, Exercise Physiology and Sarcopenia Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. The core provides standardized, state-of-the-art technologies to measure muscle performance, functional limitations, and disability in human and animal studies for OAIC’s pilot and exploratory projects and for several OAIC related projects funded through other sources.
Services Request Form
Alan Jette, Ph.D.
Thomas Storer, Ph.D.
The FAC represents a strategic interdisciplinary alliance between the Muscle Mechanics and Metabolomics Laboratory, the Laboratory of Exercise Physiology and Physical Performance and the Health and Disability Research Institute at Boston University and the Nutrition, Exercise Physiology and Sarcopenia Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. The core provides standardized, state-of-the-art technologies to measure muscle performance, functional limitations, and disability in human and animal studies for OAIC’s pilot and exploratory projects and for several OAIC related projects funded through other sources.
Services Request Form
Biostatistical Design & Analysis Core (BDAC)
Core Director: Thomas G. Travison, Ph.D.
The BDAC provides collaborative support in the design, execution and analysis of clinical trials and epidemiology studies conducted at the Boston OAIC. Additionally, the BDAC provides mentoring and collaborative opportunities for students and junior faculty in quantitative aspects of the study of physical function and impairments in aging. The BDAC is equipped to provide critical services on a consulting basis (e.g. in an advisory capacity in critical review of study data collection procedures) and more formally (e.g. in conducting simulation studies and power calculation). Furthermore, the BDAC provides support for ongoing projects by providing critical review and expertise in evaluating study conduct, or more extensive, pre-specified contributions to trial objectives. Support services for study completion are also available in providing guidance and assistance in statistical analyses, as well as co-authorship of abstracts and manuscripts describing study results.
Services Request Form
The BDAC provides collaborative support in the design, execution and analysis of clinical trials and epidemiology studies conducted at the Boston OAIC. Additionally, the BDAC provides mentoring and collaborative opportunities for students and junior faculty in quantitative aspects of the study of physical function and impairments in aging. The BDAC is equipped to provide critical services on a consulting basis (e.g. in an advisory capacity in critical review of study data collection procedures) and more formally (e.g. in conducting simulation studies and power calculation). Furthermore, the BDAC provides support for ongoing projects by providing critical review and expertise in evaluating study conduct, or more extensive, pre-specified contributions to trial objectives. Support services for study completion are also available in providing guidance and assistance in statistical analyses, as well as co-authorship of abstracts and manuscripts describing study results.
Services Request Form
Small Animal Phenotyping Core (SAPC)
Core Director: Ravi Jasuja, Ph.D.
An essential component of the preclinical proof-of-concept studies of function promoting therapies is the assessment of their effects on body composition, muscle performance and physical function. Also, the ability to genetically modify laboratory rodents has increased the need to reproducibly and quantifiably assess the phenotype of these animals with respect to body composition and physical function. The Small Animal Resource Core (SARC) provides the necessary support and infrastructure for these services by providing a focal point for interdisciplinary collaboration by Boston OAIC investigators in the application of existing and new tools and instruments to assess muscle impairments, metabolic alterations and quantification of physical function response to the function promoting therapies. Additionally, the SARC provides standardized, state-of-the-art methods and instruments to assess body composition (lean body mass, whole body and regional fat mass, skeletal muscle mass) in animal models of aging and in response to function promoting therapies, standardized equipment and operating protocols for the assessment of muscle performance and physical function in preclinical models of aging, enriched populations of muscle progenitor cells from animal models, and is able to implement and maintain personnel training and certification for the application of standardized muscle performance and physical function testing protocols, and maintain equipment calibration for use across all projects.
Request for Services
An essential component of the preclinical proof-of-concept studies of function promoting therapies is the assessment of their effects on body composition, muscle performance and physical function. Also, the ability to genetically modify laboratory rodents has increased the need to reproducibly and quantifiably assess the phenotype of these animals with respect to body composition and physical function. The Small Animal Resource Core (SARC) provides the necessary support and infrastructure for these services by providing a focal point for interdisciplinary collaboration by Boston OAIC investigators in the application of existing and new tools and instruments to assess muscle impairments, metabolic alterations and quantification of physical function response to the function promoting therapies. Additionally, the SARC provides standardized, state-of-the-art methods and instruments to assess body composition (lean body mass, whole body and regional fat mass, skeletal muscle mass) in animal models of aging and in response to function promoting therapies, standardized equipment and operating protocols for the assessment of muscle performance and physical function in preclinical models of aging, enriched populations of muscle progenitor cells from animal models, and is able to implement and maintain personnel training and certification for the application of standardized muscle performance and physical function testing protocols, and maintain equipment calibration for use across all projects.
Request for Services
Last updated: 2-15-2012
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